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Sensitivity analysesWe reassessed the influence of trial sample size on treatment effect estimates by comparing treatment effects between trials by quarters (quarter 1 v quarters https://en.wikipedia.org/wiki/Converse 2 4; quarters 1 and 2 v quarters 3 and 4; quarters 1 3 v quarter 4) and by fixed thresholds for trial sample size (50, 100, 200, 500, and 1000 patients; for example, for the 200 patient threshold, we compared treatment effects between trials with less than 200 patients and trials with 200 patients or more). We used the two stage approach to meta epidemiological analyses as described by Sterne and colleagues12 and further adjusted these analyses for the following trial characteristics: domains of risk of bias,13 14 15 16 17 overall risk of converse chuck taylor wallpapers
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